In HNSCC cell lines and mouse models, the inhibition of System Xc- or direct targeting of GPX4 induces significant ferroptosis and suppresses tumor growth; however, the therapeutic effect is diminished in strains with high SLC7A11 expression, indicating the necessity for patient stratification based on SLC7A11 expression levels [58]. The gene discussed is GPX4; the disease is head and neck squamous cell carcinoma.