Upstream, transcription factors such as NRF2 (NFE2L2) and ATF4 are known to upregulate SLC7A11 transcription, conversely, the tumor suppressor BAP1 represses SLC7A11 expression via H2A deubiquitination, thereby modulating cellular susceptibility to disulfidptosis [129]. Here, NFE2L2 is linked to neoplasm.