VSIG2 and gastric cancer: To explore the key molecules that regulate the progression of GC, we integrated and analyzed data from the TCGA and GEO databases (GSE26942, GSE27342 and GSE163558) and found that VSIG2 was significantly differentially expressed (|log2(fold change)| ≥ 1 andP  < 0.05) in GC tissues (Figure 1A).