Conversely, K48/K11-linked ubiquitin chains assembled by FBXW7 or TRIM65 target ANXA2 for 26S proteasomal degradation, leading to protein loss in FBXW7-deficient esophageal squamous cell carcinoma and conferring chemoresistance by upregulating MAPK signaling[25]. Here, FBXW7 is linked to esophageal squamous cell carcinoma.