Conversely, a significant positive correlation was observed between PDIA4 expression and the IC50 values of 53 anti-tumor drugs, such as Dactinomycin, Epirubicin, Irinotecan, Mitoxantrone, Topotecan, Olaparib, Sabutoclax, Oxaliplatin, Camptothecin and Teniposide (P < 0.05) (Fig. 6A-C, Table S4). The gene discussed is PDIA4; the disease is neoplasm.