Additionally, SPARC is implicated in various biological processes, such as obesity [17, 18], wound healing [19], inflammation [20], and cancers [21, 22], etc. Furthermore, SPARC plays a significant role in diabetes; research indicates that it promotes collagen formation and inhibits adipogenesis through the enhancement of beta-catenin signaling [17, 23]. This evidence concerns the gene SPARC and obesity due to melanocortin 4 receptor deficiency.