Furthermore, stereotactic injection of insoluble α-synuclein from brains of patients with DLB and recombinant α-synuclein fibrils into wild-type mouse brains resulted in abnormal phosphorylation of endogenous mouse α-synuclein and its time- and region-dependent propagation from the injection site [324]. The gene discussed is SNCA; the disease is Lewy body dementia.