When compared to the effect of recombinant PEAR1 on tumor cell growth and expression of p27, the effect of a suppression of LOXL2 in tumor cells was much smaller (Fig. 6C and D), indicating that binding and sequestration of LOXL2 by PEAR1 can only partially explain the dormancy-inducing activity of PEAR1. This evidence concerns the gene PEAR1 and neoplasm.