After intravenous injection of E0771, RM1 or B16F10 tumor cells, Cdh5-CreERT2;Pear1flox/flox mice (EC-Pear1-KO) showed a significantly higher number of lung metastasis compared to the controls in all tumor types (Fig. 3A and Suppl. The gene discussed is PEAR1; the disease is neoplasm.