When we tested the effect of CTSD, LOXL2 and SEMA6D on tumor cell growth and tumor cell dormancy, CTSD and LOXL2, but not SEMA6D, increased MDA-MB-231 tumor cell growth and decreased the percentage of p27-positive tumor cells in the presence of endothelial cells (Fig. 6H and I; Suppl. The gene discussed is CTSD; the disease is neoplasm.