Interaction of PEAR1 with LOXL2 appeared likely to be involved in the effects of PEAR1, since LOXL2 has previously been shown to promote tumor cell proliferation and metastasis and to inhibit tumor cell dormancy [22–24], effects which would be blocked by PEAR1-mediated sequestration of LOXL2. This evidence concerns the gene LOXL2 and neoplasm.