PEAR1 and neoplasm: EC-Pear1-KO mice had unchanged primary tumor growth compared to the controls (Fig. 4B and C) but had a significant increase in lung metastatic nodules and overall metastatic burden (Fig. 4D-G), which were visible in the case of E0771 tumors both as micro- and macrometastases (Fig. 4D, E and G) and in the case of B16F10 tumors only as micrometastases (Fig. 4F, G and Suppl.