Of these 5 candidates, PEAR1, BMP6, THBS1 and CCL2 could be validated as their knock-down in HUVECs allowed tumor cells to regain proliferation with an increased Ki67 index while having a decreased percentage of p27-positive and Ki67-negative tumor cells (Fig. 2D-G and Suppl. This evidence concerns the gene PEAR1 and neoplasm.