Pan-cancer analysis revealed that FMR1 mRNA expression was significantly upregulated in several cancer types, including cholangiocarcinoma (CHOL, P < 0.001), colon adenocarcinoma (COAD, P < 0.001), esophageal carcinoma (ESCA, P < 0.001), head and neck squamous cell carcinoma (HNSC, P < 0.001), lung squamous cell carcinoma (LUSC, P < 0.05), liver hepatocellular carcinoma (LIHC, P < 0.001), and stomach adenocarcinoma (STAD, P < 0.001) (Fig. 1A). The gene discussed is FMR1; the disease is carcinoma of esophagus.