Kaplan-Meier analysis of the 80 patients revealed that clinicopathological factors independently associated with MPM prognosis included PSS, abdominal circumference, PCI score, intraoperative blood loss, ascites, vascular tumor thrombus, lymph node metastasis, preoperative CD8+ T lymphocyte count, and IL-17 value (P < 0.05) (Supplementary Table S1). This evidence concerns the gene CD8A and metastatic malignant neoplasm in the lymph nodes.