CDKN2A and cancer: CDKN2A is a growth suppressor gene that encodes p16(INK4a)/p14(ARF) and is directly associated with tumor immunity, thought to be a prognostic marker in a variety of cancers (Chen et al, 2021; Romagosa et al, 2011; Tong et al, 2011; Zhao et al, 2016).