Consistent with this, there was evidence of generally low CD274 mRNA in public PCa data although CD274 expression was significantly higher in high IGF1/IGFBP5 tumors (Fig. 4A-B) and at the protein level (mIF) in central tumor of men with high serum IGF-1 (Fig. 4E). This evidence concerns the gene IGF1 and posterior cortical atrophy.