General ‘immune-related’ pathways included regulation of JNK cascade, inactivated in all 3 cell lines, and ‘systemic lupus erythematosus’, activated in DU145 and 22Rv1 and containing many complement, Fc receptor and HLA encoding genes (www.genome.jp/entry/pathway+hsa05322). The gene discussed is MAPK8; the disease is systemic lupus erythematosus.