To explore the possible mechanism of SARS-CoV-2-induced blood disorders and inflammation by elevating IL-6 and IL-17, we carried out molecular docking to investigate PPIs between SARS-CoV-2 spike protein (S) and either unliganded IL-6R and IL-17R or complex forms IL-6/IL-6R and IL-17/IL-17R. This evidence concerns the gene IL17A and hematologic disorder.