NKX2-1 and lung carcinoma: Additionally, we compared risk groups with important clinical confounders68 such as mutation status of frequently mutated genes in lung cancer as well as other known covariates, including sex, age, ECOG performance status, smoking status, tumor grade, thyroid transcription factor 1 (TTF-1) expression, and growth pattern, and found no relevant association (Supplementary Fig. 16. 17; Supplementary Data 7).