Single-cell RNA sequencing revealed that KRAS/TP53-driven cancer cells contribute to T cell dysfunction as well as pro-tumorigenic behaviors of macrophages, as evidenced by the infiltration of immunosuppressive subtypes of T cells (LAG3+CD8+T and LAG3+CTLA4+CD8+T) and enrichment of FOLR2+LYVE1+ macrophage subtypes which are associated with poor prognosis [68]. Here, KRAS is linked to cancer.