This finding is particularly significant given that HLA-C*08:02-restricted tumor-infiltrating lymphocytes consisting of four unique T-cell clonotypes, could specifically target KRASG12D, suggesting that treatment with CD8+T cells could lead to regression of lung metastases with metastatic colorectal cancer expressing both mutant KRASG12D and HLA-C*08:02 [42]. The gene discussed is HLA-C; the disease is metastatic colorectal cancer.