Among these cytokines, TNF could induce the CD4+CD25+FoxP3+Treg differentiation, CSF1 and CCL22 drive the differentiation of F4/80+CD11b+ monocytes to macrophages, and IL-23 inhibited CD8+T cell infiltration and promoted inflammation and tumor incidence [28, 29]. This evidence concerns the gene FOXP3 and neoplasm.