RRP8 and cancer: Interestingly, beyond local-2 jumps (i.e., clusters of two rearrangements) as described above, we also found three instances of ‘DUP-NML-DUP-NML-DUP’43–45 (i.e., known as local-3-jumps in the cancer field2) involving three local rearrangements (Supplementary Fig. 9a).