On the one hand, as a unique ligand for TNFR (TNFR1 and TNFR2), it suppresses inflammatory cascades and inhibits Th1 and Th17 helper T-cell activity, alleviating conditions such as osteoarthritis, autoimmune uveitis (EAU), and experimental autoimmune encephalomyelitis (EAE) [39, 53]. This evidence concerns the gene TNFRSF1A and osteoarthritis.