PFKFB3 and Hyperglycemia: Metabolic disruption also extends to thrombotic mechanisms: platelet activation requires a glycolytic ATP surge mediated by HK2 and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), while hyperglycemia stiffens clots via advanced glycation end-product (AGE) crosslinking.