This mTOR-driven anabolic shift, while adaptive in peripheral nerves, exhibits divergent outcomes in the central nervous system, where chronic mTORC1 activation in astrocytes drives pathological lipid synthesis and droplet accumulation via DGAT1/PLIN2 upregulation, directly linking mTOR to maladaptive glial reactivity and impaired recovery in chronic stroke phases [35, 189]. The gene discussed is MTOR; the disease is Stroke.