Additionally, we found a significant upregulation of p-β-catenin and GSK-3β, and a significant downregulation of CELSR2, β-catenin, p-GSK-3β and cyclinD1 in the CELSR2-KD group compared to the control group in the tumor nodule, as assessed by RT-qPCR (Fig. 6H). Here, CCND1 is linked to neoplasm.