Seeking mechanistic insights into the glycolysis-promoting effects of KDM6A-pSer829 in HNSCC, a GO analysis of HN6 cells showed that expressing KDM6AS829D significantly changed gene expression in rhythmic process pathway compared to expressing KDM6AS829A (Fig. 4D and Supplementary Fig. 4A). The gene discussed is KDM6A; the disease is head and neck squamous cell carcinoma.