These interactions functionally connect epigenetic regulation with metabolic control, positioning KDM6A as a molecular bridge between chromatin remodeling and cellular metabolism during tumor development, as supported by our pathway analysis (Supplementary Fig. 3A–E).To identify which protein(s) mediate the translocation of KDM6A-pSer829, we transfected phospho-mimic KDM6AS829D, KDM6AS829E, and phospho-dead KDM6AS829A into HEK293 cells and performed co-IP and LC/MS assays. Here, KDM6A is linked to neoplasm.