The levels of IL-1β, TNF-α, CXCL1/GRO-α, IL-10, CCL2/MCP-1, CCL5/RANTES, CXCL8/IL-8, CXCL10/IP-10, CCL20/MIP-3α, and CCL24/EOTAXIN-2 were significantly increased in the supernatants of ATRA-treated APL cells after 5 days (Fig. 5D). The gene discussed is CXCL8; the disease is acute promyelocytic leukemia.