Comparison of preliminary plasma cytokine and chemokine profiles from 39 APL patients and 18 healthy donors revealed significant differences in Eotaxin, GROα, IL-1α, IL-1β, IL-10, IL-15, IL-1Ra, IL-2Ra, IL-5, IL-6, IL-8, IP-10, M-CSF, MCP-1, MIP-1β, RANTES, SCGFb, SDF-1a, and TNF-α. This evidence concerns the gene IL6 and acute promyelocytic leukemia.