This hypothesis was based on previous reports showing that several natural products, including polyphenolics, such as quercetin, tetrandrine and resveratrol all induce ferroptosis in cancer cells [24–29] and it has recently been reported that these compounds also bind NR4A1 and exhibit inverse NR4A1 agonist activity [30–33] similar to that observed for DIM-3,5 analogs [18]. Here, NR4A1 is linked to cancer.