PARP1 and neoplasm: Our results clearly indicate that neddylation (i) promotes G2/M cell cycle progression of two FP-RMS cell lines, (ii) protects them from Caspase- and PARP1-dependent programmed cell death and senescence, and (iii) supports the capacity of single tumor cells to survive over time growing into a colony, all abilities that were markedly hindered by MLN4924.