Moreover, downregulation of CD36 was observed when SDHB was overexpressed, which is in agreement with the findings that CD36 protein levels in tumor samples were higher in SDH-deficient GIST patients than in SDH-competent GIST patients and confirmed that the upregulation of CD36 and lipid uptake was due to SDHB deficiency. This evidence concerns the gene SDHB and gastrointestinal stromal tumor.