Succinate is an “oncometabolite” that promotes tumorigenesis by inducing DNA hypermethylation8 and inhibiting prolyl hydroxylase, thus upregulating hypoxia-inducible factor 1a, which transcriptionally activates hypoxia-induced signaling, including vascular endothelial growth factor receptor (VEGFR) and insulin growth factor receptor (IGF1R).9 In addition, studies attemptting to unravel the molecular mechanism of SDH-deficient GISTs found that KIT and FGF receptor 1 (FGFR1) are the most highly expressed receptor tyrosine kinases (RTKs) in this type of cancer. The gene discussed is SDHB; the disease is cancer.