Second, RNA sequencing and lipidomic analyses using banked tumor samples from GIST patients collected at the collaborating hospital revealed significant glycerol lipid enrichment in the tissues of SDH-deficient patients compared with non-SDH-deficient patients, with the overexpression of genes related to lipid uptake, including CD36, FABPs, and FATPs. Among these genes, CD36 is a major player in metabolic tissues.31,32 CD36 accounts for 50% of FA uptake in adipose tissues and muscle in mice. Here, CD36 is linked to gastrointestinal stromal tumor.