Moreover, gene set enrichment analysis (GSEA) revealed that hypoxia and the HIF-1 transcription network pathways were enriched in patients who experienced a PR (Supplementary Fig. 2c), indicating that olverembatinib might exert its antitumor effects on SDH-deficient GISTs by targeting the HIF pathway, which affects tumor cell metabolism. This evidence concerns the gene HIF1A and neoplasm.