Because FTO loss mediates the reversal of EMT and hence impairs PDAC cell motility and invasiveness, we used autochthonous LSL-KrasG12D/+; Trp53R172H/+; Pdx1-Cre (KPC) pancreatic tumor-bearing mice and produced FKPC mice by introducing the FTOflox/flox allele. The gene discussed is PDX1; the disease is pancreatic neoplasm.