YAP1 and non-small cell lung carcinoma: In osimertinib-sensitive NSCLC cells, YAP1 exists predominantly as phosphorylated YAP1 (p-YAP1) in the cytoplasm, whereas in osimertinib-resistant NSCLC cells, YAP1 undergoes dephosphorylation and is translocated to the nucleus [15].