SMAD3 and lung cancer: To go further, these RNAseq datasets were mapped onto the lung cancer-specific reference network (Fig. 7B and Supplementary Fig. S7) and showed that HGF treatment alone resulted in an activated network profile similar to Fig. 1A, with activation of the same six positively influential TFs of the major regulatory node: ETS1, FOSL1, SMAD3, HMGA2, CCND1 and RUNX1 (Fig. 7B).