In addition, the expression of mesenchymal marker and collagen was significantly reduced when Wnt5a was silenced in myofibroblasts treated with TGF-β76 indicating the role of Wnt5a in the development of liver fibrosis through the regulation of TGF-β-mediated myofibroblast differentiation and fibrogenesis. This evidence concerns the gene WNT5A and Hepatic fibrosis.