SDHB and hereditary pheochromocytoma-paraganglioma: The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Management of Metastatic and/or Unresectable Pheochromocytoma and Paraganglioma from 2021 present an association between germline predisposition of a pathogenic SDHB variant and increased likelihood of metastatic disease (93).