HLA-C and cancer: In the same year, Jones et al. (Jones, Miyauchi et al. 2024) used AlphaFold to reveal significant structural differences in the HPV E5 protein between low‐ and high‐risk genotypes, highlighting its potential role in HPV‐associated cancer development and Mikhaylov et al. (Mikhaylov et al. 2024) introduced an AlphaFold‐based pipeline for accurate modeling of peptide‐MHC complexes, outperforming existing tools and advancing structural immunology and neoantigen prediction.