To further evaluate the specific role of SIAH2 in patients with hyperglycemia and determine whether its upregulation reflects active repair processes or purely pathological manifestations, we performed SIAH2 knockdown in HUVECs and HaCaT cells under different glucose concentrations and conducted Transwell assays (S6 Fig,S7, A, 7B Figs). This evidence concerns the gene SIAH2 and Hyperglycemia.