HMGA1 and cancer: Motivated by our prior results illustrating that HMGA1 sequestration reduced cancer cell characteristics, we engineered 1) an adenovirus vector containing an exogenous gene encoding an HMGA1 artificial antisense transcript (AAT) and 2) an adenovirus vector containing an exogenous gene encoding an HMGA1 shRNA transcript (shRNA), both designed to suppress HMGA1 translation and to block HMGA1 protein synthesis.