However, serum and tissue levels of CXCL1/KC and IL-6 were elevated during infection, and both AZD5148 and bezlotoxumab were effective in lowering CXCL1/KC and IL-6 levels in sera (p < 0.0001), but not in tissue (S3K–S3L Fig). This evidence concerns the gene CXCL1 and infection.