Further support for Module_8’s association with schizophrenia comes from its constituent genes, many of which are implicated in disease pathophysiology (Fig. 3B), including MEG3 (an long non-coding RNA (lncRNA) upregulated in peripheral blood of female schizophrenia patients) [56], ROBO2 (a GWAS-identified susceptibility gene) [57], CACNA1B (a voltage-gated calcium channel subunit critical for synaptic plasticity) [58], and GRIN2B (a risk locus in GWAS/transcriptomic meta-analyses encoding the NR2B subunit of the NMDA receptor) [59]. The gene discussed is MEG3; the disease is schizophrenia.