For example, left-half colon cancer has high expression of epiregulin (EREG) and amphiregulin (AREG) proteins (Lee et al. 2016), while right-half colon cancer has high mutation rates of the TGFbR2 and BRAF genes (Missiaglia et al. 2014). This evidence concerns the gene TGFBR2 and colonic neoplasm.