The top 20 pathways ranked by P-values are shown in Fig. 4C and were primarily enriched in pathways, such as cancer, endocrine resistance, chemical carcinogenesis-reactive oxygen species, phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt), IL-17, vascular endothelial growth factor, and forkhead box O (FoxO) signalling. The gene discussed is AKT1; the disease is cancer.