In multivariable analysis, high CD40 RNA expression was significantly associated with liver and bile duct (odds ratio [OR] 5.4, 95% confidence interval [CI] 1.9–15.0, P < 0.001), pancreatic (OR 4.5, 95% CI 2.3–8.8, P < 0.001), and ovarian (OR 4.4, 95% CI 2.1–9.2, P < 0.001) cancers (Table 1). Here, CD40 is linked to cancer.