Using t-SNE dimensionality reduction of markers detected via multicolor flow cytometry, encompassing transcript factors and cell phenotype indicators (Supplementary Table 2), we found that CD8+ T cells from the peripheral blood of healthy individuals, as well as from the peripheral blood, para-tumoral IEL and LPL, and tumor tissues of patients, were distinctly separated (Fig. 1g, left). Here, LPL is linked to neoplasm.