TNF and neoplasm: Compared to both BT_CD103N_B and the overall peripheral CD8+ T cell population (CRC_B_CD8T), BT_CD103N_T cells exhibited higher expression of CCL3 and TNFRSF9, which are associated with antigen-specific T cell responses, as well as effector mediators linked to anti-tumor potential, including IFNG, TNF, GZMB, PRF1, and GNLY (Fig. 7c).