PRF1 and neoplasm: Both CD103P cells (T_CD103P) and CD103N cells (T_CD103N) infiltrating in tumor tissues exhibited increased expression of anti-tumor genes, including those encoding for cytokines (TNF, IFNG), cytotoxic molecules (GZMB, GZMK, PRF1, GNLY, FASLG, LAMP3), and chemokine ligands, compared to their counterparts in peripheral blood (CRC_B_CD8) and non-tumor tissues (N_CD103P and N_CD103N) (Fig. 2c).