PCSK9 and familial hyperaldosteronism: This disease is caused by genetic mutation(s) in the LDL receptor (LDLR) and its associated genes, including apolipoprotein B, proprotein convertase subtilisin/kexin type 9, and LDLR adaptor protein 1.4, 5, 6, 7 Globally, several diagnostic criteria for FH are available, including the Dutch Lipid Clinic Network criteria, Simon–Bloom criteria, and Japan Atherosclerosis Society criteria,8, 9, 10 and FH is generally diagnosed based on clinical signs of FH, such as family history or physical findings (cutaneous and/or tendon xanthomas) or the presence of pathogenic FH-variant.