After correcting for multiple comparisons, genetically proxied downregulation of IL‐6 signaling through either of the 2 instruments in the IL6R locus was not associated with arteriolosclerotic cSVD‐related imaging biomarkers (WMH volume, deep/mixed CMBs, extensive basal ganglia EPVS) or arteriolosclerosis burden assessed by autopsy (Figure 3). Here, IL6 is linked to arteriolosclerosis.