Specifically, there was a nominal association between genetically proxied IL‐6 signaling downregulation and lower odds of large artery stroke (OR per 18% decrement in CRP levels, 0.87 [95% CI, 0.78–0.97]; P=0.01), but no significant evidence of association with TOAST‐defined small vessel stroke, MRI‐confirmed lacunar stroke, nonlobar intracerebral hemorrhage, or vascular dementia. This evidence concerns the gene IL6 and small vessel stroke.