However, we found no significant evidence that genetically proxied downregulation of IL‐6 signaling is associated with cSVD‐related clinical outcomes including TOAST‐defined small vessel stroke (OR, 1.02 [95% CI, 0.95–1.10]; P=0.54), MRI‐confirmed lacunar stroke (OR, 0.95 [95% CI, 0.81–1.11]; P=0.50), nonlobar intracerebral hemorrhage (OR, 1.04 [95% CI, 0.72–1.50]; P=0.84), or vascular dementia (OR, 1.09 [95% CI, 0.95–1.25]; P=0.221, Figure 2A). Here, IL6 is linked to vascular dementia.