HP is a known anti‐angiogenic downregulating VEGF expression.[47, 48] HP is a natural ligand for HBEGF, which contributes to tumor angiogenesis and regulates tumor vessel density.[25] We hypothesized HP‐NPs would modulate proangiogenic signals produced by GB cells, including VEGF and HBEGF. Here, HBEGF is linked to neoplasm.