HBEGF and neoplasm: Highly chemoresistant MES‐like cells, called persister GSCs sheltered in tumor vascular niche, are characterized by upregulation of four genes including HBEGF, target of HP‐NPs.[51] We demonstrated that phenotypically stable GSCs expressing high levels of HBEGF[52] sheltered in perivascular niches could be targeted by HP‐NP delivered systemically.