Thisdecrease was significant in the tumor tissues of early onset BC patients.Further, PI16 expression was negatively correlated with the overallsurvival of TNBC patients (n = 404) although notwith other subtypes (luminal A, luminal B, and HER2+). Therefore, the increased expression in PI16in the urinary proteome could reflect changes in posttranslationalPI16 processing, increased secretion, or wider changes that are notoccurring in BC tissues. This evidence concerns the gene PI16 and breast cancer.