ERBB2 and breast cancer: Thisdecrease was significant in the tumor tissues of early onset BC patients.Further, PI16 expression was negatively correlated with the overallsurvival of TNBC patients (n = 404) although notwith other subtypes (luminal A, luminal B, and HER2+). Therefore, the increased expression in PI16in the urinary proteome could reflect changes in posttranslationalPI16 processing, increased secretion, or wider changes that are notoccurring in BC tissues.