Overexpression of PI16 inHCC tissue did not affect cell proliferation, migration, or invasionbut was linked to poor survival rates. With pancreatic ductal adenocarcinoma (PDAC), overexpression ofPI16 promotes proliferation through 2′-5′-oligoadenylatesynthetase-like (OASL) activity. Interestingly,high OASL mRNA expression was correlated with favorable overall survivalamong HER2-overexpressing BC patients. This evidence concerns the gene PI16 and pancreatic ductal adenocarcinoma.