Some of the targeted proteinsappeared to be linked to the extracellular and structural componentsof the cell, namely, fibrinogen gamma chain isoform gamma-B and alpha-actinin-1.Detection of these cellular structural proteins in the urine proteomewould suggest considerable shedding of these proteins into the circulatorysystem, possibly through cellular lysis or the production of extracellularvesicles in the tumor microenvironment. Here, ACTN1 is linked to neoplasm.