ACTN1 and breast cancer: Alpha-actinin-1 is a major componentof the cytoskeleton molecule,which contributes to actin filament cross-linking proteins (F-actin)., Via α-catenin links, F-actin interacts with integrin adhesions. α-Actinin-1 could be the prognostic markerfor BC, specifically the basal-like (ER−) subtype.