Among APOE ε4 carriers, those in eGDR quartile 4 had a 14% lower dementia risk (HR: 0.86, 0.76-0.98) and a BAG that was 1.77 years younger (β: −1.77, −2.34-−1.19), compared to carriers in eGDR quartile 1 (Supplementary Figure S2 and Supplementary Tables S4 and S5). Here, APOE is linked to dementia.