We searched PubMed, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL) for reports published before March 31, 2025 using the search terms “glucagon-like peptide 1 receptor agonists (GLP-1 RAs)”, “sodium glucose cotransporter 2 inhibitors (SGLT2i), “steroidal or non-steroidal mineralocorticoid receptor antagonists”, and “mineralocorticoid receptor antagonists (MRAs)”, “randomized controlled trials”, “death”, “heart failure (HF)”, “hospitalization for heart failure”, and “death form cardiovascular causes”. This evidence concerns the gene SLC5A2 and hydrops fetalis.