In the additive NMA, the combination of MRA, SGLT2i, and GLP-1 RA was the most effective in reducing the risk of HF hospitalization (P-score 1.00; Appendix Table S4), followed by MRA and GLP-1 RA (P-score 0.77), SGLT2i and GLP-1 RA (P-score 0.74), and MRA and SGLT2i (P-score 0.64). This evidence concerns the gene GLP1R and hydrops fetalis.