Among the double combinations, MRA and GLP-1 RA strategies were the most effective in the reduction in the risk of HF hospitalization (P-score 0.77) and cardiovascular death (P-score 0.75), while SGLT2 and GLP-1 RA strategies were the most effective in the reduction in the risk of the composite endpoint (P-score 0.77). This evidence concerns the gene GLP1R and hydrops fetalis.