BTK: Bruton tyrosine kinase, IBR: Ibrutinib, TIR: Tirabrutinib, ACB: Acalabrutinib, CLL/SLL: Chronic lymphocytic leukemia/small lymphocytic lymphoma, MCL: Mantle cell lymphoma, WM/LPL: Waldenström's Macroglobulinemia/Lymphoplasmacytic lymphoma, PCNSL: Primary central nervous system lymphoma. This evidence concerns the gene BTK and primary central nervous system lymphoma.