PKD2 and autosomal dominant polycystic kidney disease: PGT-M is an effective method for the early detection and prevention of genetic diseases being transmitted from parents to children. In our study, we describe the successful implementation of combined PGT-M and PGT-A to select embryos for a woman carrying a VUS variant in the PKD2 gene causing ADPKD, who underwent ICSI and conceived a healthy fetus.