Moreover, plasminogen and tissue plasminogen activator (tPA) intraperitoneal administration can induce motor neurons degeneration in mice (Demestre et al., 2006), and urokinase-type plasminogen activator (uPA) exhibits higher expression in the ventral horn of the spinal cord of G93A SOD1 mice and ALS patients (Glas et al., 2007). The gene discussed is PLG; the disease is amyotrophic lateral sclerosis.