TARDBP and amyotrophic lateral sclerosis: Indeed, after the evidence that TDP-43 was essential for normal skeletal muscle formation by assembling cytoplasmic amyloid-like structures called myo-granules (Vogler et al., 2018), which gave rise to the discussion about its beneficial or detrimental role in muscle cells physiology and pathology (McHugh, 2019), several works have tried to uncover its specific role in this tissue (Šušnjar et al., 2022; Versluys et al., 2022) and also its possible implications in the context of ALS (Versluys et al., 2022; Cykowski et al., 2018; Mori et al., 2019).