RAB5A and amyotrophic lateral sclerosis: Interestingly, this group included genes such as CadN, which encodes an important hub molecule implicated in neurodevelopmental and neurodegenerative diseases (László and Lele, 2022), and Rab5, whose encoded protein was shown to accumulate in the cytoplasm of spinal cord neurons of patients with ALS (Sanhueza et al., 2015).