TARDBP and amyotrophic lateral sclerosis: The fruit fly Drosophila melanogaster has long been established as a great tool to study neurodegenerative diseases (Marsh and Thompson, 2006) including ALS (Hegde and Srivastava, 2022), and a series of transgenic and knock-out models of TDP-43-mediated ALS have been generated and characterized (Romano et al., 2012).