PLAT and amyotrophic lateral sclerosis: Moreover, plasminogen and tissue plasminogen activator (tPA) intraperitoneal administration can induce motor neurons degeneration in mice (Demestre et al., 2006), and urokinase-type plasminogen activator (uPA) exhibits higher expression in the ventral horn of the spinal cord of G93A SOD1 mice and ALS patients (Glas et al., 2007).