NEDD4 and amyotrophic lateral sclerosis: Effectively, numerous genes taking part in the enriched neuronal processes were previously associated with ALS and in general with neurodegeneration, like Atx2 and Nedd4. Atx2, a gene already associated with ALS, is essential for cytoskeletal dynamics and neurodevelopment; its depletion causes multiple morphological defects in the nervous system of third instar larvae, including impaired axon development and decreased dendrite outgrowth (Del Castillo et al., 2021).