SPARC-like 1 (SPARCL1), a member of the acidic secretory protein family, inhibited the expression of phosphorylated p38/c-JNK/ERK MAPKs, suggesting that it suppressed RCC cell migration and invasion via the inactivation of p38/JNK/ERK MAPKs (Ye et al., 2017). This evidence concerns the gene MAPK1 and renal cell adenocarcinoma.