The RUNX family—RUNX1 (Runt-related transcription factor 1), RUNX2 (Runt-related transcription factor 2), and RUNX3 (Runt-related transcription factor 3)—has been implicated in both normal development and oncogenesis, with RUNX3 functioning as a tumor-suppressor gene across multiple malignancies. The gene discussed is RUNX2; the disease is neoplasm.