Conversely, lncRNA P73 antisense RNA 1T (TP73-AS1) can inhibit the expression of KISS1 (KiSS-1 metastasis-suppressor) by interacting with EZH2, which results in PI3K/AKT/mTOR pathway suppression, inhibition of apoptosis, and consequent enhancement of RCC proliferation and invasion (Liu et al., 2018). This evidence concerns the gene AKT1 and renal cell carcinoma.