LETM1 (leucine zipper-EF-hand containing transmembrane protein 1), UBE3C, and miR-543 promote the proliferation, migration, and invasiveness of RCC cells by activating the Wnt/β-catenin signaling pathway (Xu et al., 2018; Wen et al., 2015; Chen et al., 2018). The gene discussed is LETM1; the disease is renal cell adenocarcinoma.