AKT1 and renal cell carcinoma: Macrophage-derived exosome miR-342-3p inhibits NEDD4L, which subsequently inhibits CEP55 ubiquitination and degradation by activating the PI3K/AKT/mTOR signaling pathway, upregulating CEP55 protein expression, and promoting the growth and metastasis of RCC cells (Feng et al., 2021).