Whereas miR-106b, miR-134 and miR-514a-3p suppress RCC invasion and migration through MAPK-related signaling, has-miR-15b-5p, has-miR-99b-5p, and has-miR-181a-5p have been demonstrated to interact directly with MMP-2 and MMP-9, thereby inhibiting RCC invasion, migration, and proliferation (Király et al., 2024). This evidence concerns the gene MMP2 and renal cell adenocarcinoma.