Inhibitor of growth 4 (ING4) inhibits the expression of dual specificity phosphatases (DUSP4) and activates the p38 MAPK pathway in RCC cells, thereby upregulating the expression of type I IFN-stimulated genes and promoting RCC cell proliferation and metastasis (Tang et al., 2022). This evidence concerns the gene DUSP4 and renal cell adenocarcinoma.