Neovascularisation is orchestrated through the coordinated activation of the vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and mammalian target of rapamycin (mTOR) signaling axes, whose induction supplies nutrients and oxygen while facilitating tumor cell dissemination (Négrier and Raymond, 2012). The gene discussed is VEGFA; the disease is neoplasm.