In addition, some proteins such as micropeptide MIAC, SPARCL1, ING4, DUSPs, RASAL2, some compounds such as Fisetin, Alpha-Mangostin, Rhein, Gαi1, Morusin, and miRNAs such as miR-106b, miR-134, miR-514a-3p, also inhibited the invasion, migration, and proliferation of RCC cells by regulating the MAPK pathway or its related signaling pathways. The gene discussed is SPARCL1; the disease is renal cell carcinoma.