AKT1 and renal cell adenocarcinoma: HOXA transcript at the distal tip (HOTTIP) is a newly discovered lncRNA, which can not only inhibit autophagy through the PI3K/AKT/Atg13 signaling pathway (Su et al., 2019) and promote RCC cell proliferation, migration, and invasion, but also exert similar effects by upregulating miR-506 (Zhang C. et al., 2024).