Yue Wang et al. first reported that ferroptosis is involved in DN by exploring the role of ferroptosis in the progression of DN via in vivo and in vitro experiments and reported that the expression of the ferroptosis-related protein GPX4 was decreased, ACSL4 expression was increased, and lipid peroxide products and iron content were also increased in mouse models of DN (Wang et al., 2020). The gene discussed is ACSL4; the disease is liver dysplastic nodule.