CHEK2 and colorectal carcinoma: Similarly, PRDM16-DT encoded by LINC00982 directly interacts with hnRNPA2B1 and competitively reduces the binding of the hnRNPA2B1 phase to exon 9 of checkpoint kinase 2 (CHEK2), leading to long CHEK2 (L-CHEK2) formation in CRC [217].