Recent studies in ccRCC found that lncRNA tropomyosin 3 pseudogene 9 encodes a novel protein, TPM3P9, which interacts with splicing factor RNA-binding motif protein 4 (RBM4), inhibiting RBM4-mediated exon skipping of transcription factor 7-like 2 (TCF7L2), resulting in increased long splice variant TCF7L2-L expression [113]. The gene discussed is TCF7L2; the disease is nonpapillary renal cell carcinoma.