CRHR1 and Anxiety: Importantly, in animal models of AUD, blockade of CRHR1 has consistently shown efficacy in reducing anxiety, alcohol consumption and relapse behavior (Sommer et al., 2008; Gehlert et al., 2007; Simms et al., 2014; Cottone et al., 2009; Funk et al., 2006), establishing the progressive sensitization of the amygdala CRH system during the development of dependence as one of the most robust finding in animal models of addiction (Heilig et al., 2011).