Mechanistically, beyond Th2 cytokine modulation, Shu et al. (2022) demonstrated in an IgE-mediated murine allergy model that Lico-A suppresses PLC/ERK/STAT3 signaling, thereby inhibiting mast cell activation and reducing tumor necrosis factor-α (TNF-α) and MCP-1 release to attenuate inflammatory responses—further elucidating its anti-allergic mechanisms (Shu et al., 2022). The gene discussed is TNF; the disease is allergic disease.