MTOR and melanoma: In a parallel study focusing on melanoma, Zhang et al. (2020) demonstrated that Lico-A enhances the expression of Ras homologous protein enriched in the brain by activating miR-142-3p, thereby activating the mTOR signaling pathway, inhibiting proliferation, reducing melanin production, and inducing apoptosis in A375 and B16 melanoma cells (Zhang et al., 2020).